|
Fetal Growth Retardation
|
0.400 |
ModifyingMutation
|
phenotype |
RGD |
Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta.
|
24239160 |
2014 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
RGD |
To investigate the expressions of the insulin receptor (IR), insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), phosphatidyl inositol 3-kinase (PI3K) and insulin-like growth factor-1 (IGF-1) of the livers of the male adult rats born with intrauterine growth retardation (IUGR),and to find out the relationship between IUGR and insulin resistance in their adult life.
|
19088829 |
2008 |
|
Fetal Growth Retardation
|
0.400 |
Therapeutic
|
phenotype |
RGD |
To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet.
|
15506645 |
2004 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
LHGDN |
Low intrauterine IGF-I serum levels may account for thinner and stiffer umbilical arteries in IUGR infants in comparison to AGA infants thereby providing a potential link to arterial hypertension in adulthood.
|
19070892 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
LHGDN |
There was a significant positive correlation between aIMT and gestational age, whereas a significant negative correlation was determined between aIMT and IGF-I in the IUGR neonates.
|
17957164 |
2007 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.
|
21823995 |
2011 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
There was no significant difference in the levels of transcripts for IGF1, insulin receptor, or IGF2R between normal and IUGR term placentas.
|
9491374 |
1998 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Early T depressed serum insulin-like growth factor 1 and caused intrauterine growth restriction (IUGR; P < 0.0005).
|
30095996 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, at 28 weeks' gestation there was increased IGF2 (3.9-fold), placental growth hormone (2.7-fold), and IGF BP2 (2.1-fold) expression in maternal blood in women destined to develop FGR at term (P < .05).
|
23583218 |
2013 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Changes in GH/IGF-1 axis in intrauterine growth retardation: consequences of fetal programming?
|
19623512 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Intraplacental gene transfer of IGF-1 prevents FGR induced cardiac dysfunction.
|
28099426 |
2017 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In addition to imprinted genes, the microarray data highlighted non-imprinted genes acting in endocrine signaling (LEP, CRH, HPGD, INHBA), tissue growth (IGF1), immune modulation (INDO, PSG-family genes), oxidative metabolism (GLRX), vascular function (AGTR1, DSCR1) and metabolite transport (SLC-family solute carriers) as differentially expressed in IUGR vs. non-IUGR placentae.
|
16125225 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Insulin-like growth factor I gene deletion causing intrauterine growth retardation and severe short stature.
|
9401537 |
1997 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The FGR(W)-FGR(L) infants showed the lowest mean values of IGF1 (126.2+/-3.2) and IGFBP3 (0.86+/-0.03).
|
16835759 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate that the molecular machinery necessary for transcriptional control of proliferation remains intact in IUGR fetal myoblasts, indicating that in vivo factors such as reduced insulin and IGF1, hypoxia and/or elevated counter-regulatory hormones may be inhibiting muscle growth in IUGR fetuses.
|
28053000 |
2017 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Similar perturbations could be observed in human intrauterine growth retardation suggesting the IGF/IGFBP system is involved in fetal growth, biomineralization, and energetic status in humans.
|
16809446 |
2006 |
|
Fetal Growth Retardation
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The pathogenic <i>IGF1R</i> mutation in this girl led to intrauterine growth retardation followed by partial postnatal catch-up growth.
|
30859796 |
2019 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In this hypothetical scenario, IUGR-induced deficit of IGF-1 causes "diabetic" aging trajectory associated with various metabolic disorders in adulthood, while fetal macrosomia-induced excessive levels of IGF-1 lead to "cancerous" aging trajectory.
|
29626501 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated IGF binding protein (IGFBP)-1 expression associated with fetal growth restriction has been documented.
|
18772238 |
2009 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The results showed FBG, FINS and HOAM-IR in CUG-FGR group were higher than those in high fat feeding control group (NC+HF), but the content of IGF-1 in blood was lower than that in NC + HF group.
|
29442728 |
2018 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Women in the IUGR group were smaller than in the control group (p < 0.05), and, using the covariance test (p < 0.05), this was found to be correlated with IGF-I levels but not with EGF or TGF-beta levels.
|
11903419 |
2001 |
|
Fetal Growth Retardation
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
There were significantly lower concentrations of glucose, insulin, IGF-1, and IGF-II in the fetal cord blood of pregnancies with IUGR (p<0.05).
|
20106611 |
2010 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Decreased placental expression levels of hPGH, IGF-I and IGFBP-1 were demonstrated in pregnancies with FGR.
|
21212012 |
2011 |
|
Fetal Growth Retardation
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.
|
15134305 |
2004 |